Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Acetyl chloride → 5-Bromo-4-chloroisatoic anhydride
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Acetyl chloride | HCID 6367 | — |
| 반응물 | Ethyl chloroformate | HCID 10928 | — |
| 반응물 | 2-Amino-5-bromo-4-chlorobenzoic acid | HCID 19612050 | — |
| 생성물 | 5-Bromo-4-chloroisatoic anhydride | HCID 86608392 | 70% |
반응 단계
7.5 g (30 mmol) of 2-amino-5-bromo-4-chloro-benzoic acid was heated under reflux with 18 mL of ethyl chloroformate for 6 h, and was further heated under reflux for another 3 h after addition of 18 mL of acetyl chloride. The solid was collected and washed with hexanes to produce 5.8 g (70%) of 5-bromo-4-chloroisatoic anhydride. LCMS: 277 (M+1)+.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US07893267B2 |
| 출처 데이터셋 | uspto-grants-2011_02 |
| ORD ID | ord-0c0d4bbab2b2488593fe27b1cc1022b6 |
| 출처 메모 | uspto-grants-2011_02 |