2-[3-(4-Methylpiperazino)-3-oxopropyl]phenyl N-octadecylcarbamate → 2-[3-(4-Methylpiperazino)-3-oxopropyl]phenyl N-octadecylcarbamate hydrochloride

HRID 1368370노트

반응식

HRID 1368370 반응식
[ClH:1].C(OCC)(=O)C.[CH2:8]([NH:26][C:27](=[O:46])[O:28][C:29]1[CH:34]=[CH:33][CH:32]=[CH:31][C:30]=1[CH2:35][CH2:36][C:37]([N:39]1[CH2:44][CH2:43][N:42]([CH3:45])[CH2:41][CH2:40]1)=[O:38])[CH2:9][CH2:10][CH2:11][CH2:12][CH2:13][CH2:14][CH2:15][CH2:16][CH2:17][CH2:18][CH2:19][CH2:20][CH2:21][CH2:22][CH2:23][CH2:24][CH3:25]>C(OCC)(=O)C>[ClH:1].[CH2:8]([NH:26][C:27](=[O:46])[O:28][C:29]1[CH:34]=[CH:33][CH:32]=[CH:31][C:30]=1[CH2:35][CH2:36][C:37]([N:39]1[CH2:40][CH2:41][N:42]([CH3:45])[CH2:43][CH2:44]1)=[O:38])[CH2:9][CH2:10][CH2:11][CH2:12][CH2:13][CH2:14][CH2:15][CH2:16][CH2:17][CH2:18][CH2:19][CH2:20][CH2:21][CH2:22][CH2:23][CH2:24][CH3:25]

참가 물질

4

반응물 2

HCID 98074162-[3-(4-Methylpiperazino)-3-oxopropyl]phenyl N-octadecylcarbamateHCID 21866389Hydrogen chloride-ethyl acetate

생성물 1

HCID 185202882-[3-(4-Methylpiperazino)-3-oxopropyl]phenyl N-octadecylcarbamate hydrochloride

시약·촉매·용매 1

HCID 8857Ethyl Acetate용매

실험 절차

4N Hydrochloric acid/ethyl acetate solution (0.11 ml) was added to a solution containing 2-[3-(4-methylpiperazino)-3-oxopropyl]phenyl N-octadecylcarbamate (0.20 g) in ethyl acetate (2 ml) while being cooled with ice. After being stirred for 20 minutes, the reaction mixture was concentrated. The residue was recrystallized with the mixed solution of ethyl acetate-ethanol, thereby yielding the entitled compound (0.19 g) as white solid.

후처리

  1. temperaturewhile being cooled with ice
  2. concentrationthe reaction mixture was concentrated
  3. customThe residue was recrystallized with the mixed solution of ethyl acetate-ethanol

출처 및 근거

ORD 기록
ord-a0a4488ec65b4f4d8870f2576ea8cbe5
출처 데이터셋
uspto-grants-2003_06
특허 번호
US06573297B2

반응 노트

불러오는 중…