5-Chlorooxindole → 5-(5-Chloro-2-oxo-1,2-dihydroindol-3-ylidenemethyl)-4-methyl-1H-pyrrole-2-carboxylic acid ethyl ester

HRID 1368410노트

반응식

HRID 1368410 반응식
[Cl:1][C:2]1[CH:3]=[C:4]2[C:8](=[CH:9][CH:10]=1)[NH:7][C:6](=[O:11])[CH2:5]2.[CH2:12]([O:14][C:15]([C:17]1[NH:18][C:19]([CH:23]=O)=[C:20]([CH3:22])[CH:21]=1)=[O:16])[CH3:13]>>[CH2:12]([O:14][C:15]([C:17]1[NH:18][C:19]([CH:23]=[C:5]2[C:4]3[C:8](=[CH:9][CH:10]=[C:2]([Cl:1])[CH:3]=3)[NH:7][C:6]2=[O:11])=[C:20]([CH3:22])[CH:21]=1)=[O:16])[CH3:13]

참가 물질

3

반응물 2

HCID 1528015-ChlorooxindoleHCID 9855648Ethyl 5-formyl-4-methyl-1H-pyrrole-2-carboxylate

생성물 1

HCID 672810735-(5-Chloro-2-oxo-1,2-dihydroindol-3-ylidenemethyl)-4-methyl-1H-pyrrole-2-carboxylic acid ethyl ester수율 94%

실험 절차

5-Chloro-1,3-dihydroindol-2-one (2.22 g, 13.2 mmol) was condensed with 5-formyl-4-methyl-1H-pyrrole-2-carboxylic acid ethyl ester (2.43 g) using method E to give 4.1 g (94%) of the title compound as an orange solid.

출처 및 근거

ORD 기록
ord-264f2c2395a147628c77fa8179397123
출처 데이터셋
uspto-grants-2003_06
특허 번호
US06573293B2

반응 노트

불러오는 중…