HCID 178418816, 화합물 → HCID 178487501, 화합물

HRID 1368519노트

반응식

HRID 1368519 반응식
[NH:1]1[CH:5]=[C:4]([C:6]([C:8]2[CH:17]=[CH:16][C:15]3[C:10](=[CH:11][CH:12]=[C:13]([O:18][CH3:19])[CH:14]=3)[CH:9]=2)=[O:7])[N:3]=[CH:2]1.[CH2:20]([Mg]Br)[CH:21]([CH3:23])[CH3:22]>C1COCC1>[NH:1]1[CH:5]=[C:4]([C:6]([C:8]2[CH:17]=[CH:16][C:15]3[C:10](=[CH:11][CH:12]=[C:13]([O:18][CH3:19])[CH:14]=3)[CH:9]=2)([OH:7])[CH2:20][CH:21]([CH3:23])[CH3:22])[N:3]=[CH:2]1

참가 물질

4

반응물 2

HCID 178418816HCID 178418816, 화합물HCID 178487490HCID 178487490, 화합물

생성물 1

HCID 178487501HCID 178487501, 화합물

시약·촉매·용매 1

HCID 8028Tetrahydrofuran용매

실험 절차

In a similar manner to that described in Example 1-(iv), the reaction of (1H-imidazol-4-yl)-(6-methoxynaphthalen-2-yl)ketone (0.60 g) with absolution of isobutylmagnesium bromide in THF (1.0 M, 2.4 ml) was carried out to give the titled compound (0.14 g) as a colorless solid.

출처 및 근거

ORD 기록
ord-dc1d339bc98e42a4b37c0346034510b4
출처 데이터셋
uspto-grants-2003_06
특허 번호
US06573289B1

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