Triethylamine → 1-(1-Acetoxymethyl-1H-imidazol-4-yl)-1-(6-methoxynaphthalen-2-yl)-2-methyl-1-propanol

HRID 1368525

반응식

HRID 1368525 반응식
[NH:1]1[CH:5]=[C:4]([C:6]([C:11]2[CH:20]=[CH:19][C:18]3[C:13](=[CH:14][CH:15]=[C:16]([O:21][CH3:22])[CH:17]=3)[CH:12]=2)([OH:10])[CH:7]([CH3:9])[CH3:8])[N:3]=[CH:2]1.[C:23]([O:26][CH2:27]Br)(=[O:25])[CH3:24].C(N(CC)CC)C>C1COCC1>[C:23]([O:26][CH2:27][N:1]1[CH:5]=[C:4]([C:6]([C:11]2[CH:20]=[CH:19][C:18]3[C:13](=[CH:14][CH:15]=[C:16]([O:21][CH3:22])[CH:17]=3)[CH:12]=2)([OH:10])[CH:7]([CH3:9])[CH3:8])[N:3]=[CH:2]1)(=[O:25])[CH3:24]

참가 물질

5

반응물 3

HCID 8471TriethylamineHCID 68536Bromomethyl acetateHCID 178487492HCID 178487492, 화합물

생성물 1

HCID 220184171-(1-Acetoxymethyl-1H-imidazol-4-yl)-1-(6-methoxynaphthalen-2-yl)-2-methyl-1-propanol수율 24.1%

시약·촉매·용매 1

HCID 8028Tetrahydrofuran용매

실험 절차

1-(1H-Imidazol-4-yl)-1-(6-methoxynaphthalen-2-yl)-2-methyl-1-propanol (100 mg) was dissolved in THF (6 ml), and to the solution were added bromomethyl acetate (160 mg) and triethylamine (40 mg). The mixture was stirred at room temperature for 2 h. The reaction mixture was concentrated, and the residue was purified by silica gel chromatography (eluent, dichloromethane-methanol=20:1) to give the titled compound (30 mg) as a colorless solid.

후처리

  1. concentrationThe reaction mixture was concentrated
  2. customthe residue was purified by silica gel chromatography (eluent, dichloromethane-methanol=20:1)

출처 및 근거

ORD 기록
ord-7a39e942a0bc4c38ba41fc43aaec1887
출처 데이터셋
uspto-grants-2003_06
특허 번호
US06573289B1

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