HCID 22018329, 화합물 → HCID 178458193, 화합물

HRID 1368537노트

반응식

HRID 1368537 반응식
[CH:1]([O:4][C:5]1[CH:6]=[C:7]2[C:12](=[CH:13][CH:14]=1)[CH:11]=[C:10]([C:15]([C:20]1[N:21]=[CH:22][N:23](C(C3C=CC=CC=3)(C3C=CC=CC=3)C3C=CC=CC=3)[CH:24]=1)([OH:19])[CH:16]([CH3:18])[CH3:17])[CH:9]=[CH:8]2)([CH3:3])[CH3:2]>C(O)(=O)C.O>[CH:1]([O:4][C:5]1[CH:6]=[C:7]2[C:12](=[CH:13][CH:14]=1)[CH:11]=[C:10]([C:15]([C:20]1[N:21]=[CH:22][NH:23][CH:24]=1)([OH:19])[CH:16]([CH3:18])[CH3:17])[CH:9]=[CH:8]2)([CH3:2])[CH3:3]

참가 물질

4

반응물 1

HCID 22018329HCID 22018329, 화합물

생성물 1

HCID 178458193HCID 178458193, 화합물수율 67.8%

시약·촉매·용매 2

HCID 176Acetic Acid용매HCID 962Water용매

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온도
50 °C

실험 절차

1-(6-Isopropoxynaphthalen-2-yl)-2-methyl-1-(1-trityl-1H-imidazol-4-yl)-1-propanol (0.438 g) was dissolved in a mixture of acetic acid (20 ml) and water (0.5 ml), and the solution was stirred at 50° C. for 18 h. The solvent was evaporated, and to the mixture was added ethyl acetate. The mixture was washed with saturated aqueous solution of sodium hydrogencarbonate and saturated sodium chloride solution. The organic layer was dried and concentrated. The obtained residue was purified by silica gel column chromatography (eluent, dichloromethane:methanol=40:1→20:1) to give the titled compound (0.170 g) as an amorphous product.

후처리

  1. customThe solvent was evaporated
  2. additionto the mixture was added ethyl acetate
  3. washThe mixture was washed with saturated aqueous solution of sodium hydrogencarbonate and saturated sodium chloride solution
  4. customThe organic layer was dried
  5. concentrationconcentrated
  6. customThe obtained residue was purified by silica gel column chromatography (eluent, dichloromethane:methanol=40:1→20:1)

출처 및 근거

ORD 기록
ord-c51d8eb8d17e4290ab134e3548f294cd
출처 데이터셋
uspto-grants-2003_06
특허 번호
US06573289B1

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