Toluene → HCID 178435532, 화합물

HRID 1368558노트

반응식

HRID 1368558 반응식
BrC1C=C2C(=CC=1)[CH:8]=[C:7]([C:12]([C:17]1[N:18]=[CH:19][N:20](C(C3C=CC=CC=3)(C3C=CC=CC=3)C3C=CC=CC=3)[CH:21]=1)([OH:16])[CH:13]([CH3:15])[CH3:14])[CH:6]=[CH:5]2.[CH2:41](C([Sn])=C(CCCC)CCCC)CCC.[C:56]1([CH3:62])[CH:61]=[CH:60][CH:59]=[CH:58][CH:57]=1>C1C=CC([P]([Pd]([P](C2C=CC=CC=2)(C2C=CC=CC=2)C2C=CC=CC=2)([P](C2C=CC=CC=2)(C2C=CC=CC=2)C2C=CC=CC=2)[P](C2C=CC=CC=2)(C2C=CC=CC=2)C2C=CC=CC=2)(C2C=CC=CC=2)C2C=CC=CC=2)=CC=1>[CH2:62]([C:56]1[CH:61]=[C:60]2[C:59](=[CH:58][CH:57]=1)[CH:8]=[C:7]([C:12]([C:17]1[N:18]=[CH:19][NH:20][CH:21]=1)([OH:16])[CH:13]([CH3:15])[CH3:14])[CH:6]=[CH:5]2)[CH3:41]

참가 물질

5

반응물 3

HCID 1140TolueneHCID 22018349HCID 22018349, 화합물HCID 53438229Tri(butyl)vinyltin

생성물 1

HCID 178435532HCID 178435532, 화합물

시약·촉매·용매 1

HCID 178418397HCID 178418397, 화합물촉매

실험 절차

A solution of 1-(6-bromonaphthalen-2-yl)-2-methyl-1-(1-trityl-1H-imidazol-4-yl)-1-propanol (2.0 g), tetrakis(triphenylphosphine)palladium (116 mg) and tributylvinyltin (1.40 ml) in toluene (30 ml) was refluxed under argon atmosphere for 80 min. The solvent was distilled off and the residue was purified by column chromatography (eluent, hexane:THF=2:1),then crystallized from isopropyl ether-hexane (1:1) to give the titled compound (1.47 g) as a colorless powder.

후처리

  1. distillationThe solvent was distilled off
  2. customthe residue was purified by column chromatography (eluent, hexane
  3. customTHF=2:1),then crystallized from isopropyl ether-hexane (1:1)

출처 및 근거

ORD 기록
ord-9f165b7ede0e476da5876cebb700d18a
출처 데이터셋
uspto-grants-2003_06
특허 번호
US06573289B1

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