Ddctp → 2',3'-Dideoxyuridine-5'-triphosphate

HRID 1368572노트

반응식

[P:1]([O:13][CH2:14][C@H:15]1[O:19][C@@H:18]([N:20]2[CH:27]=[CH:26][C:24](N)=[N:23][C:21]2=[O:22])[CH2:17][CH2:16]1)([O:4][P:5]([O:8][P:9]([OH:12])([OH:11])=[O:10])([OH:7])=[O:6])(=[O:3])[OH:2].N([O-])=[O:29].[Na+].C(O)(=O)C>>[P:1]([O:13][CH2:14][C@H:15]1[O:19][C@@H:18]([N:20]2[CH:27]=[CH:26][C:24](=[O:29])[NH:23][C:21]2=[O:22])[CH2:17][CH2:16]1)([O:4][P:5]([O:8][P:9]([OH:11])([OH:12])=[O:10])([OH:7])=[O:6])(=[O:3])[OH:2]

참가 물질

반응물 2

HCID 119119Ddctp

HCID 86611488NaNO2 acetic acid

생성물 1

HCID 722452',3'-Dideoxyuridine-5'-triphosphate

실험 절차

The derivative was synthesized via the unstable diazonium derivative starting with the commercially available 2′,3′-dideoxy-cytidine-5′-triphosphate (Boehringer Mannheim) by deamination with NaNO2/acetic acid.

출처 및 근거

ORD 기록: ord-810df20c1e8148f297e8f84737b4c819
출처 데이터셋: uspto-grants-2003_06
DOI: 10.6084/m9.figshare.5104873.v1
특허 번호: US06573374B1

반응 노트

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