Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Pyrazole → HCID 55272722, 화합물
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Pyrazole | HCID 1048 | — |
| 반응물 | Potassium Carbonate | HCID 11430 | — |
| 반응물 | 5-Fluoro-1-indanone | HCID 136537 | — |
| 용매 | Dimethyl Sulfoxide | HCID 679 | — |
| 용매 | Diethyl Ether | HCID 3283 | — |
| 생성물 | HCID 55272722 | HCID 55272722 | 73% |
반응 단계
Combine 5-fluoro-indan-1-one (1.02 g, 6.79 mmol), pyrazole (0.46 g, 6.79 mmol), and potassium carbonate (1.03 g, 7.47 mmol, 1.10 equivalents) in dimethyl sulfoxide (5 ml) in a sealed tube and heat to 100° C. for 48 hours. Cool to room temperature, dilute with ether, wash with water (2×), dry over anhydrous sodium sulfate, and concentrate to obtain the title compound as a brown solid (0.98 g, 73%). LC-MS m/z 199.1 (M++1).
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US07728150B2 |
| 출처 데이터셋 | uspto-grants-2010_06 |
| ORD ID | ord-f4d7115efd174a5987f52d7c0fd3251e |
| 출처 메모 | uspto-grants-2010_06 |