Isonicotinic Acid → 2,5-Pyrrolidinedione, 1-[(4-pyridinylcarbonyl)oxy]-
반응식
[C:1]([OH:9])(=[O:8])[C:2]1[CH:7]=[CH:6][N:5]=[CH:4][CH:3]=1.O[N:11]1[C:15](=[O:16])[CH2:14][CH2:13][C:12]1=[O:17]>C1COCC1>[C:1]([O:9][N:11]1[C:15](=[O:16])[CH2:14][CH2:13][C:12]1=[O:17])(=[O:8])[C:2]1[CH:7]=[CH:6][N:5]=[CH:4][CH:3]=1참가 물질
4
실험 절차
A mixture of isonicotinic acid (3 g), N-hydroxysuccinimide (2.79 g) and N,N-dicyclohexylcarbodiimide (5.52 g) was stirred in THF (200 mL) for 16 hours. The solid was filtered off and the solvent evaporated under reduced pressure. The residue was triturated with ethyl acetate and more solid filtered off. The filtrates were concentrated under reduced pressure gave 2,5-dioxopyrrolidin-1-yl isonicotinate (5.27 g). MS: 221 [MH]+.
후처리
- filtrationThe solid was filtered off
- customthe solvent evaporated under reduced pressure
- customThe residue was triturated with ethyl acetate and more solid
- filtrationfiltered off
- concentrationThe filtrates were concentrated under reduced pressure
출처 및 근거
- ORD 기록
- ord-484efae79cfc4124ad2aa9afdd3a06d9
- 출처 데이터셋
- uspto-grants-2003_06
- 특허 번호
- US06576630B1
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