Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
4-Pentynoic acid, 1,1-dimethylethyl ester → 1-(2-Diethylaminoethyl)-4-trifluoromethyl-6-(4-t-butoxycarbonyl-1-butynyl)-3-hydroxy-3-(2-naphthyl)oxindole
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | 4-Pentynoic acid, 1,1-dimethylethyl ester | HCID 10877341 | — |
| 반응물 | 1-(2-Diethylaminoethyl)-4-trifluoromethyl-6-iodo-3-hydroxy-3-(2-naphthyl)oxindole | HCID 11827896 | — |
| 생성물 | 1-(2-Diethylaminoethyl)-4-trifluoromethyl-6-(4-t-butoxycarbonyl-1-butynyl)-3-hydroxy-3-(2-naphthyl)oxindole | HCID 18518554 | 82% |
반응 단계
The title compound (34.9 mg, 82%) was prepared from 1-(2-diethylaminoethyl)-4-trifluoromethyl-6-iodo-3-hydroxy-3-(2-naphthyl)oxindole of Example 48 (40.9 mg, 0.0720 mmol) and 4-t-butoxycarbonyl-1-butyne by the procedure similar to that described in Reference Example 21.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US06576656B1 |
| 출처 데이터셋 | uspto-grants-2003_06 |
| ORD ID | ord-9e9fbdedf6fc41c88f484378cb7d8890 |
| 출처 메모 | uspto-grants-2003_06 |