HCID 18518556, 화합물 → HCID 18518619, 화합물

반응식

[CH2:1]([N:3]([CH2:22][CH3:23])[CH2:4][CH2:5][N:6]1[C:16]2[C:11](=[C:12]([C:18]([F:21])([F:20])[F:19])[CH:13]=[CH:14][C:15]=2[I:17])[C:9](=[O:10])[C:7]1=[O:8])[CH3:2].[CH:24]1[C:33]2[C:28](=[CH:29][CH:30]=[CH:31][CH:32]=2)[CH:27]=[CH:26][C:25]=1[Mg]Br>>[CH2:22]([N:3]([CH2:1][CH3:2])[CH2:4][CH2:5][N:6]1[C:16]2[C:11](=[C:12]([C:18]([F:20])([F:21])[F:19])[CH:13]=[CH:14][C:15]=2[I:17])[C:9]([OH:10])([C:26]2[CH:25]=[CH:24][C:33]3[C:28](=[CH:29][CH:30]=[CH:31][CH:32]=3)[CH:27]=2)[C:7]1=[O:8])[CH3:23]

참가 물질

반응물 2

HCID 18518556HCID 18518556, 화합물

HCID 178418423HCID 178418423, 화합물

생성물 1

HCID 18518619HCID 18518619, 화합물수율 53%

실험 절차

The title compound (103 mg, 53%) was prepared from 1-(2-diethylaminoethyl)-7-iodo-4-trifluoromethylisatin (152 mg, 0.345 mmol) and 2-naphthylmagnesium bromide by the procedure similar to that described in Example 1.

출처 및 근거

ORD 기록: ord-b4029a6aa0794ecebc4bd071cd229958
출처 데이터셋: uspto-grants-2003_06
DOI: 10.6084/m9.figshare.5104873.v1
특허 번호: US06576656B1

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