Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Hydrochloric Acid → 1-Methyl-4,6-dichloroisatin
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Hydrochloric Acid | HCID 313 | — |
| 반응물 | Methyl iodide | HCID 6328 | — |
| 반응물 | Sodium hydride | HCID 24758 | — |
| 반응물 | 4,6-Dichloroisatin | HCID 251908 | — |
| 용매 | Tetrahydrofuran | HCID 8028 | — |
| 생성물 | 1-Methyl-4,6-dichloroisatin | HCID 18518537 | 84% |
반응 단계
A mixture of 60% NaH (20.5 mg), 4,6-dichloroisatin (947 mg), and iodomethane (0.328 mL) in THF (20 mL) were stirred overnight at room temperature, poured into 1 N hydrochloric acid, and extracted with ethyl acetate. The extracts were washed with sat. aqueous NaCl, dried over MgSO4, and concentrated. The residue was washed with hexane to give the title compound (849 mg, 84%).
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US06576656B1 |
| 출처 데이터셋 | uspto-grants-2003_06 |
| ORD ID | ord-ead5a8352e254e4fac6704b9d6f66aa2 |
| 출처 메모 | uspto-grants-2003_06 |