Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Pyridine → n-(1h-Indol-7-yl)methanesulfonamide
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Pyridine | HCID 1049 | — |
| 반응물 | Methanesulfonyl chloride | HCID 31297 | — |
| 반응물 | 7-Aminoindole | HCID 111634 | — |
| 용매 | Dichloromethane | HCID 6344 | — |
| 생성물 | n-(1h-Indol-7-yl)methanesulfonamide | HCID 20231824 | 94% |
반응 단계
Stir 1H-indol-7-ylamine with pyridine (1 equivalent) and methanesulfonyl chloride (1 equivalent) in dichloromethane for 12 hrs. Wash the reaction with 1N hydrochloric acid and water, dry over magnesium sulfate, and evaporate. Recrystallize the residue from isopropanol to obtain the title product as a purple solid (94%). MS (ES+), 210 (M), MS (ES−), 209 (M−1). LC/MS shows 95% purity.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US07728150B2 |
| 출처 데이터셋 | uspto-grants-2010_06 |
| ORD ID | ord-54e3deaf4b5a4dd0936ca7f5174fa939 |
| 출처 메모 | uspto-grants-2010_06 |