Pyridine → n-(1h-Indol-7-yl)methanesulfonamide

HRID 13693

반응식

HRID 13693 반응식
[NH:1]1[C:9]2[C:4](=[CH:5][CH:6]=[CH:7][C:8]=2[NH2:10])[CH:3]=[CH:2]1.N1C=CC=CC=1.[CH3:17][S:18](Cl)(=[O:20])=[O:19]>ClCCl>[NH:1]1[C:9]2[C:4](=[CH:5][CH:6]=[CH:7][C:8]=2[NH:10][S:18]([CH3:17])(=[O:20])=[O:19])[CH:3]=[CH:2]1

참가 물질

5

반응물 3

HCID 1049PyridineHCID 31297Methanesulfonyl chlorideHCID 1116347-Aminoindole

생성물 1

HCID 20231824n-(1h-Indol-7-yl)methanesulfonamide수율 94%

시약·촉매·용매 1

HCID 6344Dichloromethane용매

실험 절차

Stir 1H-indol-7-ylamine with pyridine (1 equivalent) and methanesulfonyl chloride (1 equivalent) in dichloromethane for 12 hrs. Wash the reaction with 1N hydrochloric acid and water, dry over magnesium sulfate, and evaporate. Recrystallize the residue from isopropanol to obtain the title product as a purple solid (94%). MS (ES+), 210 (M), MS (ES−), 209 (M−1). LC/MS shows 95% purity.

후처리

  1. washWash
  2. customthe reaction with 1N hydrochloric acid and water
  3. dry with materialdry over magnesium sulfate
  4. customevaporate
  5. customRecrystallize the residue from isopropanol

출처 및 근거

ORD 기록
ord-54e3deaf4b5a4dd0936ca7f5174fa939
출처 데이터셋
uspto-grants-2010_06
특허 번호
US07728150B2

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