Acetic Acid → 2-Bromo-1-methoxymethyl-3-methylbenzene

HRID 1369592

반응식

HRID 1369592 반응식
[Br:1][C:2]1[C:9]([CH3:10])=[CH:8][CH:7]=[CH:6][C:3]=1[CH2:4]Br.[C:11](=O)(O)[O-:12].[Na+].C(O)(=O)C>CO>[Br:1][C:2]1[C:9]([CH3:10])=[CH:8][CH:7]=[CH:6][C:3]=1[CH2:4][O:12][CH3:11]

참가 물질

5

반응물 3

HCID 176Acetic AcidHCID 516892Sodium BicarbonateHCID 109343202-Bromo-1-(bromomethyl)-3-methylbenzene

생성물 1

HCID 138434542-Bromo-1-methoxymethyl-3-methylbenzene수율 99%

시약·촉매·용매 1

HCID 887Methanol용매

실험 절차

To a stirred solution of 2-bromo-3-methylbenzylbromide (5.2 g, 0.0197 mol) in methanol (30 ml) was added saturated sodiumbicarbonate (5 ml) and the mixture was refluxed overnight. The mixture was neutralised with acetic acid and the solvent was evaporated under reduced pressure. Chromatography of the residue on silica gel using hexane:methylene chloride (7/3) as eluent gave 4.2 g (99%) of the title compound.

후처리

  1. temperaturethe mixture was refluxed overnight
  2. customthe solvent was evaporated under reduced pressure

출처 및 근거

ORD 기록
ord-71cb6ed385944d218490145813e7eb64
출처 데이터셋
uspto-grants-2003_06
특허 번호
US06579884B1

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