Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Chlorohydroquinone → Phenylpropynoic acid methyl ester
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Chlorohydroquinone | HCID 301 | — |
| 반응물 | Methanol | HCID 887 | — |
| 반응물 | Phenylacetylene | HCID 10821 | — |
| 촉매 | palladium(II) acetate | HCID 167845 | — |
| 생성물 | Phenylpropynoic acid methyl ester | HCID 138378 | — |
반응 단계
A solution of phenylacetylene (10, 2 mmol), chlorohydroquinone(HQ-Cl) (0.4 mmol), molybdovanadophosphate (NPMoV) (35 mg) and palladium (II) acetate (50 mg) in methanol (10 mL) is stirred under CO/O2 (10 atm/0.5 atm) at 25° C. for 15 h. The reaction is then quenched with wet ether and the product is extracted with n-hexane. After removal of the solvent under reduced pressure, the product is isolated by column chromatography over silica gel (hexane:ethyl acetate 5:1) to give pure methyl phenylpropiolate.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US06579988B2 |
| 출처 데이터셋 | uspto-grants-2003_06 |
| ORD ID | ord-6c1949234d864167946a004a2d2318f4 |
| 출처 메모 | uspto-grants-2003_06 |