Tri-o-tolylphosphine → Ethyl (E)-4-[2-(5,6-dihydro-5,5-dimethyl-8-(phenylthio)naphthalenyl)ethenyl]benzoate

참여 물질

역할	이름	HCID	투입량
반응물	Tri-o-tolylphosphine	HCID 80271	—
반응물	Ethyl 4-vinylbenzoate	HCID 10866858	—
반응물	4,4-Dimethyl-7-bromo-1-phenylthio-3,4-dihydronaphthalene	HCID 15896018	—
촉매	palladium(II) acetate	HCID 167845	—
용매	Triethylamine	HCID 8471	—
생성물	Ethyl (E)-4-[2-(5,6-dihydro-5,5-dimethyl-8-(phenylthio)naphthalenyl)ethenyl]benzoate	HCID 19695074	—

반응 조건

온도	90 °C

반응 단계

To a degassed solution of 0.35 g (1.0 mmol) of 2-bromo-5,6-dihydro-5,5-dimethyl-8-(phenylthio)-naphthalene (Compound A35) and 0.34 g (1.9 mmol) of ethyl 4-vinylbenzoate in 4.0 mL of triethylamine, was added 0.066 g (0.2 mmol) of tri-o-tolylphosphine and then 0.025 g (0.1 mmol) of palladium(II) acetate. The reaction was heated at 90° C. for 2.25 h. The reaction was concentrated in vacuo. The residue was purified by flash chromatography (silica, 5% ethyl acetate in hexane), followed by recrystallization using EtOH to afford the title compound as white crystals.

출처 및 근거

DOI	10.6084/m9.figshare.5104873.v1
특허 번호	US05723666
출처 데이터셋	uspto-grants-1998_03
ORD ID	ord-6359f090cbac49c6a126e41999e4f8b9
출처 메모	uspto-grants-1998_03