Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Methyl iodide → 3-(1-Ethyl-5-fluoro-indan-1-yl)-1-methyl-7-nitro-1H-indole
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Methyl iodide | HCID 6328 | — |
| 반응물 | Sodium Methoxide | HCID 10942334 | — |
| 반응물 | 3-(1-Ethyl-5-fluoro-indan-1-yl)-7-nitro-1H-indole | HCID 11609506 | — |
| 용매 | Diethyl Ether | HCID 3283 | — |
| 용매 | Dimethylformamide | HCID 6228 | — |
| 생성물 | 3-(1-Ethyl-5-fluoro-indan-1-yl)-1-methyl-7-nitro-1H-indole | HCID 11573630 | 95.6% |
반응 단계
Combine 3-(1-ethyl-5-fluoro-indan-1-yl)-7-nitro-1H-indole (0.33 g, 1.02 mmol), sodium methoxide (110 mg, 2.04 mmol), and iodomethane (0.10 ml, 1.53 mmol) in dimethylformamide (5 ml) and stir at room temperature under nitrogen overnight. Dilute with ether, wash with water (2×), dry over sodium sulfate, filter, and concentrate to obtain the title compound as a yellow amorphous solid (0.33 g, 94%). LC-MS m/z 339.1 (M++1).
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US07728150B2 |
| 출처 데이터셋 | uspto-grants-2010_06 |
| ORD ID | ord-becbe1a517f8420a8d9ed13574665c82 |
| 출처 메모 | uspto-grants-2010_06 |