Methyl iodide → 3-(1-Ethyl-5-fluoro-indan-1-yl)-1-methyl-7-nitro-1H-indole

HRID 13701

반응식

HRID 13701 반응식
[CH2:1]([C:3]1([C:13]2[C:21]3[C:16](=[C:17]([N+:22]([O-:24])=[O:23])[CH:18]=[CH:19][CH:20]=3)[NH:15][CH:14]=2)[C:11]2[C:6](=[CH:7][C:8]([F:12])=[CH:9][CH:10]=2)[CH2:5][CH2:4]1)[CH3:2].[CH3:25][O-].[Na+].IC>CN(C)C=O.CCOCC>[CH2:1]([C:3]1([C:13]2[C:21]3[C:16](=[C:17]([N+:22]([O-:24])=[O:23])[CH:18]=[CH:19][CH:20]=3)[N:15]([CH3:25])[CH:14]=2)[C:11]2[C:6](=[CH:7][C:8]([F:12])=[CH:9][CH:10]=2)[CH2:5][CH2:4]1)[CH3:2]

참가 물질

6

반응물 3

HCID 6328Methyl iodideHCID 10942334Sodium MethoxideHCID 116095063-(1-Ethyl-5-fluoro-indan-1-yl)-7-nitro-1H-indole

생성물 1

HCID 115736303-(1-Ethyl-5-fluoro-indan-1-yl)-1-methyl-7-nitro-1H-indole수율 95.6%

시약·촉매·용매 2

HCID 3283Diethyl Ether용매HCID 6228Dimethylformamide용매

실험 절차

Combine 3-(1-ethyl-5-fluoro-indan-1-yl)-7-nitro-1H-indole (0.33 g, 1.02 mmol), sodium methoxide (110 mg, 2.04 mmol), and iodomethane (0.10 ml, 1.53 mmol) in dimethylformamide (5 ml) and stir at room temperature under nitrogen overnight. Dilute with ether, wash with water (2×), dry over sodium sulfate, filter, and concentrate to obtain the title compound as a yellow amorphous solid (0.33 g, 94%). LC-MS m/z 339.1 (M++1).

후처리

  1. washwash with water (2×)
  2. dry with materialdry over sodium sulfate
  3. filtrationfilter
  4. concentrationconcentrate

출처 및 근거

ORD 기록
ord-becbe1a517f8420a8d9ed13574665c82
출처 데이터셋
uspto-grants-2010_06
특허 번호
US07728150B2

연결된 노트

불러오는 중…