Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
1-Methoxy-4-methyl-2-nitrobenzene → 4-(Bromomethyl)-1-methoxy-2-nitrobenzene
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | 1-Methoxy-4-methyl-2-nitrobenzene | HCID 67058 | — |
| 반응물 | N-bromobutanimide | HCID 67184 | — |
| 촉매 | 2,2'-Azobis(2,4-dimethyl-4-methoxyvaleronitrile) | HCID 85867 | — |
| 용매 | Dichloromethane | HCID 6344 | — |
| 생성물 | 4-(Bromomethyl)-1-methoxy-2-nitrobenzene | HCID 11579648 | 78.2% |
반응 단계
To a solution of 4-methoxy-3-nitrotoluene (5.02 g) and N-bromosuccinimide (5.51 g) in dichloromethane (50 mL) was added 2,2′-azobis(4-methoxy-2,4-dimethylvaleronitrile) (463 mg). The mixture was heated under reflux for 8 hours. The solution was washed with water and brine, dried over magnesium sulfate and evaporated in vacuo. The residue was triturated with n-hexane-ethyl acetate (20:1) to give 4-methoxy-3-nitrobenzyl bromide as a pale yellow powder (5.78 g).
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US06582351B1 |
| 출처 데이터셋 | uspto-grants-2003_06 |
| ORD ID | ord-9b00f5281c724f9a8e1e3bef3a83a71c |
| 출처 메모 | uspto-grants-2003_06 |