참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|
| 반응물 | Acetone | HCID 180 | — |
| 반응물 | Hydroquinone | HCID 785 | — |
| 반응물 | Allyl iodide | HCID 11166 | — |
| 반응물 | Potassium Carbonate | HCID 11430 | — |
| 생성물 | 4-(Allyloxy)phenol | HCID 1713883 | 41.2% |
반응 단계
Allyl iodide (8.2 mL, 89 mmoles) was added to a solution of hydroquinone (7.84 g, 71.2 mmoles) and K2CO3 (19.7 g, 142.4 mmoles) in acetone (102 mmoles). The resulting mixture was heated to 40° C. overnight and concentrated under reduced pressure. The crude products were filtered through a pad of silica with 1:1 hexanes:ethyl acetate. The residue was purified by flash chromatography on a prepacked Biotage column (hexane to 1:1 hexane:ethyl acetate) on silica gel to provide the title compound (4.40 g, 41%).
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| 특허 번호 | US06583180B2 |
|---|
| 출처 데이터셋 | uspto-grants-2003_06 |
|---|
| ORD ID | ord-27744a5ea8714d8d86bfbc104de5ee09 |
|---|
| 출처 메모 | uspto-grants-2003_06 |
|---|
