Methyl 2-(2-nitrophenyl)acetate → Methyl 2-aminobenzeneacetate
반응식
[N+:1]([C:4]1[CH:9]=[CH:8][CH:7]=[CH:6][C:5]=1[CH2:10][C:11]([O:13][CH3:14])=[O:12])([O-])=O>CO.[Pd]>[NH2:1][C:4]1[CH:9]=[CH:8][CH:7]=[CH:6][C:5]=1[CH2:10][C:11]([O:13][CH3:14])=[O:12]참가 물질
4
실험 절차
Methyl 2-nitrophenylacetate (10.1 g, 51.2 mmol) in 125 mL of methanol containing 221 mg of 10% Pd/C was placed on the Parr hydrogenator at 40 psi. After 5 h the mixture was filtered through celite and evaporated under reduced pressure to give a clear red oil. The solvent was evaporated under reduced pressure to give 8.5 g (100%) of methyl 2-aminophenylacetate as a clear red oil. TLC (silica, EtOAc/hexanes): Rf=0.24. 1H NMR (400 MHz, CDCl3): 7.21 (m, 2H), 6.86 (m, 2H), 3.81 (s, 3H), 3.70 (s, 2H).
후처리
- filtrationAfter 5 h the mixture was filtered through celite
- customevaporated under reduced pressure
- customto give a clear red oil
- customThe solvent was evaporated under reduced pressure
출처 및 근거
- ORD 기록
- ord-03fdc31774d643189fa95400874e02d0
- 출처 데이터셋
- uspto-grants-2003_06
- 특허 번호
- US06583155B2
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