Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Benzyl Bromide → 1-Benzyl-1H-benzotriazole
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Benzyl Bromide | HCID 7498 | — |
| 반응물 | Tetrahydrofuran | HCID 8028 | — |
| 반응물 | Potassium tert-butoxide | HCID 23665647 | — |
| 반응물 | HCID 178418385 | HCID 178418385 | — |
| 용매 | Water | HCID 962 | — |
| 용매 | Dimethylformamide | HCID 6228 | — |
| 생성물 | 1-Benzyl-1H-benzotriazole | HCID 521212 | 57% |
반응 단계
To a solution of benzotriazole (1.2 g, 10.1 mmol) in DMF (40 mL) at r.t. was added a solution of 1M KOtBu in THF (11 mL, 11 mmol). After stirring for 30 min., benzyl bromide (2.0 g, 11.6 mmol) was added. The mixture was further stirred for 1 h, diluted with H2O, and extracted with EtOAc. The EtOAc extract was washed with H2O (3×), dried (MgSO4) and concentrated. The residue was stirred with hexane containing small amount of Et2O to give 1.2 g (57%) of the title compound as a white powder.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US06583126B2 |
| 출처 데이터셋 | uspto-grants-2003_06 |
| ORD ID | ord-90d48bbc411049d29c20e14239b06e74 |
| 출처 메모 | uspto-grants-2003_06 |