Water → Guanine

HRID 1371278노트

반응식

HRID 1371278 반응식
[CH:1]1[NH:2][C:3]2[N:9]=[C:8]([NH2:10])[N:7]=[C:6](Cl)[C:4]=2[N:5]=1.C(N(CC)CC)C.C[O:20]C1C=C(C)C(S)=CC=1.O>CO>[NH:7]1[C:6](=[O:20])[C:4]2[NH:5][CH:1]=[N:2][C:3]=2[N:9]=[C:8]1[NH2:10]

참가 물질

6

반응물 4

HCID 962WaterHCID 8471TriethylamineHCID 27595964-Methoxy-2-methylbenzenethiolHCID 1785084356-chloro-1H-purin-2-amine

생성물 1

HCID 135398634Guanine

시약·촉매·용매 1

HCID 887Methanol용매

실험 절차

6-Chloroguanine derivative prepared in Preparation 6 (4.86 g) was dissolved in 85 ml of methanol and 1.4 g of triethylamine and 2.9 g of 4-methoxythiocresol were added. The reaction mixture was reacted under reflux condition for 24 hours. The reaction was stopped by adding 20 ml of water, and the methanol was removed by distillation under reduced pressure. The reaction mixture was extracted with dichloromethane and purified by silica gel column to give a compound wherein 6-position of guanine was substituted by 4-methoxyphenylthio group.

후처리

  1. customThe reaction mixture was reacted
  2. temperatureunder reflux condition for 24 hours
  3. customthe methanol was removed by distillation under reduced pressure
  4. extractionThe reaction mixture was extracted with dichloromethane
  5. custompurified by silica gel column

출처 및 근거

ORD 기록
ord-84d17f4f92b641489ef262c6b1c5cfc1
출처 데이터셋
uspto-grants-2007_01
특허 번호
US07157448B2

반응 노트

불러오는 중…