Benzaldehyde → Methyl (4R)-2-phenyl-1,3-thiazolidine-4-carboxylate
반응식
Cl.[CH3:2][O:3][C:4](=[O:9])[C@H:5]([CH2:7][SH:8])[NH2:6].[CH:10](=O)[C:11]1[CH:16]=[CH:15][CH:14]=[CH:13][CH:12]=1.C(N(CC)CC)C>O1CCCC1>[C:11]1([CH:10]2[NH:6][C@H:5]([C:4]([O:3][CH3:2])=[O:9])[CH2:7][S:8]2)[CH:16]=[CH:15][CH:14]=[CH:13][CH:12]=1참가 물질
5
실험 절차
To a suspension of L-cysteine methyl ester hydrochloride (1.717 g, 10 mmol) in tetrahydrofuran (5.0 mL) at room temperature under nitrogen was added benzaldehyde (1.02 mL, 10 mmol) followed by triethylamine (4.2 mL, 30 mmol). After stirring at room temperature for 3.5 hrs, the resulting mixture was filtered through a pad of silica gel eluting with EtOAc. Evaporation of the filtrate gave the title compound (1.95 g, 88%) as a colorless oil. TLC(EtOAc-hexane; 1:5) Rf=0.22.
후처리
- filtrationthe resulting mixture was filtered through a pad of silica gel eluting with EtOAc
- customEvaporation of the filtrate
출처 및 근거
- ORD 기록
- ord-2194b992c06a4819a26c6ca96d373f8c
- 출처 데이터셋
- uspto-grants-2007_01
- 특허 번호
- US07157430B2
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