Ethyl trifluoroacetate → 2,2,2-trifluoro-N-(morpholin-2-ylmethyl)acetamide

HRID 1371375노트

반응식

HRID 1371375 반응식
[NH:1]1[CH2:6][CH2:5][O:4][CH:3]([CH2:7][NH2:8])[CH2:2]1.C([O:11][C:12](=O)[C:13]([F:16])([F:15])[F:14])C>CO>[F:14][C:13]([F:16])([F:15])[C:12]([NH:8][CH2:7][CH:3]1[O:4][CH2:5][CH2:6][NH:1][CH2:2]1)=[O:11]

참가 물질

4

반응물 2

HCID 9794Ethyl trifluoroacetateHCID 45420271-(Morpholin-2-yl)methanamine

생성물 1

HCID 115502612,2,2-trifluoro-N-(morpholin-2-ylmethyl)acetamide

시약·촉매·용매 1

HCID 887Methanol용매

반응 조건

온도
22 °C

실험 절차

To a stirred solution of morpholin-2-ylmethylamine (3.1 g) in methanol (70 ml) under nitrogen was added an ethereal solution of ethyl-α,α,α-trifluoroacetate (5 ml in 20 ml ether) which had been washed with saturated aqueous sodium bicarbonate, water and brine, and dried. The mixture was stirred for 30 min at 22° C. before removal of all volatiles in vacuo. The residue was dissolved in methanol (10 ml) and the volatiles again removed in vacuo to give the title compound as a white crunchy foam (4.9 g).

후처리

  1. washhad been washed with saturated aqueous sodium bicarbonate, water and brine
  2. customdried
  3. dissolutionThe residue was dissolved in methanol (10 ml)
  4. customthe volatiles again removed in vacuo

출처 및 근거

ORD 기록
ord-952ae676d9fa4fd6ac1af444e9a5acdb
출처 데이터셋
uspto-grants-2007_01
특허 번호
US07157457B2

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