2-Aminopropanol → 2-{[(3,4-Dichlorophenyl)methyl]amino}propan-1-ol

HRID 1371401노트

반응식

HRID 1371401 반응식
[Cl:1][C:2]1[CH:3]=[C:4]([CH:7]=[CH:8][C:9]=1[Cl:10])[CH2:5]Cl.[NH2:11][CH:12]([CH3:15])[CH2:13][OH:14]>>[Cl:1][C:2]1[CH:3]=[C:4]([CH:7]=[CH:8][C:9]=1[Cl:10])[CH2:5][NH:11][CH:12]([CH3:15])[CH2:13][OH:14]

참가 물질

3

반응물 2

HCID 51262-AminopropanolHCID 76093,4-Dichlorobenzyl chloride

생성물 1

HCID 219629772-{[(3,4-Dichlorophenyl)methyl]amino}propan-1-ol수율 79%

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온도
50 °C

실험 절차

3,4-Dichlorobenzyl chloride (0.988 g) was added to 2-amino-1-propanol (4.10 g) and the mixture was stirred at 50° C. under nitrogen for 2 h. The mixture was partitioned between saturated aqueous sodium bicarbonate (100 ml) and ethyl acetate (100 ml) and the phases were separated. The organic layer was washed with water (4×100 ml) and brine, dried (Na2SO4) then concentrated under vacuum to give the title compound as a white solid (0.935 g).

후처리

  1. customThe mixture was partitioned between saturated aqueous sodium bicarbonate (100 ml) and ethyl acetate (100 ml)
  2. customthe phases were separated
  3. washThe organic layer was washed with water (4×100 ml) and brine
  4. dry with materialdried (Na2SO4)
  5. concentrationthen concentrated under vacuum

출처 및 근거

ORD 기록
ord-fc91a1e74e0f49db8cc2e334f08fcc05
출처 데이터셋
uspto-grants-2007_01
특허 번호
US07157457B2

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