Allyl isocyanate → N-Allyl-N'-{[4-(3,4-dichlorobenzyl)morpholin-2-yl]methyl}urea

HRID 1371411

반응식

HRID 1371411 반응식
[Cl:1][C:2]1[CH:3]=[C:4]([CH:14]=[CH:15][C:16]=1[Cl:17])[CH2:5][N:6]1[CH2:11][CH2:10][O:9][CH:8]([CH2:12][NH2:13])[CH2:7]1.[N:18]([CH2:21][CH:22]=[CH2:23])=[C:19]=[O:20]>>[CH2:21]([NH:18][C:19]([NH:13][CH2:12][CH:8]1[O:9][CH2:10][CH2:11][N:6]([CH2:5][C:4]2[CH:14]=[CH:15][C:16]([Cl:17])=[C:2]([Cl:1])[CH:3]=2)[CH2:7]1)=[O:20])[CH:22]=[CH2:23]

참가 물질

3

반응물 2

HCID 15123Allyl isocyanateHCID 10308229[4-(3,4-Dichlorobenzyl)morpholin-2-yl]methylamine

생성물 1

HCID 10109024N-Allyl-N'-{[4-(3,4-dichlorobenzyl)morpholin-2-yl]methyl}urea

실험 절차

Example 10 was prepared in an analogous manner to Example 1 using a mixture of Intermediate 3 (0.025 g) and 3-isocyanatoprop-1-ene (12.0 μl) to give the title compound (0.027 g). LC-MS (System A): Rt 1.93 mins, Mass Spectrum m/z 358 [MH+].

후처리

  1. customExample 10 was prepared in an analogous manner to Example 1 using

출처 및 근거

ORD 기록
ord-0f1d35f9db0e4cb6b2c2188a58fd3772
출처 데이터셋
uspto-grants-2007_01
특허 번호
US07157457B2

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