alpha-Naphthyl isocyanate → N-{[4-(3,4-Dichlorobenzyl)morpholin-2-yl]methyl}-N'-(1-naphthyl)urea

HRID 1371428

반응식

HRID 1371428 반응식
[Cl:1][C:2]1[CH:3]=[C:4]([CH:14]=[CH:15][C:16]=1[Cl:17])[CH2:5][N:6]1[CH2:11][CH2:10][O:9][CH:8]([CH2:12][NH2:13])[CH2:7]1.[N:18]([C:21]1[C:30]2[C:25](=[CH:26][CH:27]=[CH:28][CH:29]=2)[CH:24]=[CH:23][CH:22]=1)=[C:19]=[O:20]>>[Cl:1][C:2]1[CH:3]=[C:4]([CH:14]=[CH:15][C:16]=1[Cl:17])[CH2:5][N:6]1[CH2:11][CH2:10][O:9][CH:8]([CH2:12][NH:13][C:19]([NH:18][C:21]2[C:30]3[C:25](=[CH:26][CH:27]=[CH:28][CH:29]=3)[CH:24]=[CH:23][CH:22]=2)=[O:20])[CH2:7]1

참가 물질

3

반응물 2

HCID 66589alpha-Naphthyl isocyanateHCID 10308229[4-(3,4-Dichlorobenzyl)morpholin-2-yl]methylamine

생성물 1

HCID 10160685N-{[4-(3,4-Dichlorobenzyl)morpholin-2-yl]methyl}-N'-(1-naphthyl)urea

실험 절차

Example 31 was prepared in an analogous manner to Example 1 using a mixture of Intermediate 3 (0.025 g) and 1-isocyanatonaphthalene (19.6 μl) to give the title compound (0.0304 g). LC-MS (System A): Rt 2.43 mins, Mass Spectrum m/z 444 [MH+].

후처리

  1. customExample 31 was prepared in an analogous manner to Example 1 using

출처 및 근거

ORD 기록
ord-531a09b145644e41893d76345726d72a
출처 데이터셋
uspto-grants-2007_01
특허 번호
US07157457B2

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