Indole → 1H-Indole, 7-(1-piperazinyl)-

HRID 1371517노트

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HRID 1371517 반응식
[NH:1]1[C:9]2[C:4](=[CH:5][CH:6]=[CH:7][CH:8]=2)[CH:3]=[CH:2]1.BrC1C=CC=C2C=1NC=C2.C([N:27]1[CH2:32][CH2:31][NH:30][CH2:29][CH2:28]1)(OC(C)(C)C)=O.C(O)(C(F)(F)F)=O>C(Cl)Cl>[N:27]1([C:8]2[CH:7]=[CH:6][CH:5]=[C:4]3[C:9]=2[NH:1][CH:2]=[CH:3]3)[CH2:32][CH2:31][NH:30][CH2:29][CH2:28]1

참가 물질

6

반응물 4

HCID 798IndoleHCID 6422Trifluoroacetic acidHCID 143452tert-Butyl piperazine-1-carboxylateHCID 27570207-Bromoindole

생성물 1

HCID 30695021H-Indole, 7-(1-piperazinyl)-수율 54%

시약·촉매·용매 1

HCID 6344Dichloromethane용매

실험 절차

The Boc protected indole (200 mg, 1.5 mmol) prepared from 7-bromoindole and N-Boc piperazine as described in Step 1 of Preparation 54A is dissolved in DCM (1 mL). TFA (1 mL) is added and the mixture is stirred at r.t. for about an hour. The mixture is then concentrated to oil, which is taken up in methanol and freebased via SCX purification to afford about 164 mg (54%) of the final compound.

후처리

  1. concentrationThe mixture is then concentrated to oil, which
  2. customis taken up in methanol and freebased via SCX purification

출처 및 근거

ORD 기록
ord-b3442d9115a648a3bce533b88e405f98
출처 데이터셋
uspto-grants-2007_01
특허 번호
US07157463B2

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