Methanamine, N-methoxy-, hydrochloride (1:1) → 2-(N-Boc)amino-3-(4-cyanophenyl)-N-methoxy-N-methylpropanamide

참여 물질

역할	이름	HCID	투입량
반응물	Methanamine, N-methoxy-, hydrochloride (1:1)	HCID 81138	—
반응물	Diisopropylethylamine	HCID 81531	—
반응물	O-(Benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate	HCID 2733207	—
반응물	N-(tert-Butoxycarbonyl)-4-cyano-L-phenylalanine	HCID 7020841	—
용매	Dichloromethane	HCID 6344	—
생성물	2-(N-Boc)amino-3-(4-cyanophenyl)-N-methoxy-N-methylpropanamide	HCID 21070238	—

반응 단계

2 g of (N-Boc)-4-cyanophenylalanine, 2.32 g of TBTU, 2.40 ml of DIPEA and 806 mg of N,O-dimethylhydroxylamine hydrochloride are mixed together in 30 ml of DCM. After stirring for 24 hours at RT, the reaction mixture is concentrated to dryness and the residue is then extracted with EtOAc. The organic phase is washed with a pH 2 buffer solution, a saturated NaHCO3 solution and then a saturated NaCl solution. The expected compound crystallizes from a mixture of isopropyl ether and pentane (1.89 g).

출처 및 근거

DOI	10.6084/m9.figshare.5104873.v1
특허 번호	US07157454B2
출처 데이터셋	uspto-grants-2007_01
ORD ID	ord-90a6d7c751cc4148b1a4a3cdbb4e6014
출처 메모	uspto-grants-2007_01