Benzene, 1-iodo-2-(trifluoromethyl)- → (4-Amino-2-ethylsulfanyl-pyrimidin-5-yl)-(2-trifluoromethyl-phenyl)-methanone

HRID 1371613

반응식

HRID 1371613 반응식
CON(C)[C:4]([C:6]1[C:7]([NH2:15])=[N:8][C:9]([S:12][CH2:13][CH3:14])=[N:10][CH:11]=1)=[O:5].[F:17][C:18]([F:27])([F:26])[C:19]1[CH:24]=[CH:23][CH:22]=[CH:21][C:20]=1[Li].IC1C=CC=CC=1C(F)(F)F>>[NH2:15][C:7]1[C:6]([C:4]([C:20]2[CH:21]=[CH:22][CH:23]=[CH:24][C:19]=2[C:18]([F:27])([F:26])[F:17])=[O:5])=[CH:11][N:10]=[C:9]([S:12][CH2:13][CH3:14])[N:8]=1

참가 물질

4

반응물 3

HCID 67957Benzene, 1-iodo-2-(trifluoromethyl)-HCID 119748325-Pyrimidinecarboxamide, 4-amino-2-(ethylthio)-N-methoxy-N-methyl-HCID 1785066832-(Trifluoromethyl)phenyllithium

생성물 1

HCID 21070577(4-Amino-2-ethylsulfanyl-pyrimidin-5-yl)-(2-trifluoromethyl-phenyl)-methanone

실험 절차

The same procedure was used as described in Example 2, starting from 4-amino-2-ethylsulfanyl-pyrimidine-5-carboxylic acid methoxy-methylamide (from Example 1) and a solution of 2-trifluoromethylphenyllithium (˜3 equiv, freshly prepared from 1-iodo-2-trifluoromethylbenzene as in Example 2A), to give (4-Amino-2-ethylsulfanyl-pyrimidin-5-yl)-(2-trifluoromethyl-phenyl)-methanone. MS (M+H)+: 328.

출처 및 근거

ORD 기록
ord-c31d8a14dfe84d78a0dd02262da4366f
출처 데이터셋
uspto-grants-2007_01
특허 번호
US07157455B2

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