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Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
HRID 1371692생성일: 2026년 10월 26일

3-Chloropropanesulphonyl chloride → [4-Amino-2-[1-(3-chloro-propane-1-sulfonyl)-piperidin-4-ylamino]-pyrimidin-5-yl]-(2,3-difluoro-6-methoxy-phenyl)-methanone

https://huagongshe.com/reaction/1371692

반응식

참여 물질

역할이름HCID투입량
반응물3-Chloropropanesulphonyl chlorideHCID 15410—
반응물[4-Amino-2-(piperidin-4-ylamino)-pyrimidin-5-yl]-(2,3-difluoro-6-methoxy-phenyl)-methanoneHCID 10316630—
생성물[4-Amino-2-[1-(3-chloro-propane-1-sulfonyl)-piperidin-4-ylamino]-pyrimidin-5-yl]-(2,3-difluoro-6-methoxy-phenyl)-methanoneHCID 9983584—

반응 단계

The compound was prepared from [4-amino-2-(piperidin-4-ylamino)-pyrimidin-5-yl]-(2,3-difluoro-6-methoxy-phenyl)-methanone (Example 107) and chloropropanesulfonyl chloride (Aldrich) in an analogous manner as described in Example 177. HR-MS (ES, m/z) calculated for C20H25N5O4SF2CI [(M+H)+] 504.1279, observed 504.1284.

출처 및 근거

DOI10.6084/m9.figshare.5104873.v1
특허 번호US07157455B2
출처 데이터셋uspto-grants-2007_01
ORD IDord-0e3ba03d6c3d41a881faf7c2c223354c
출처 메모uspto-grants-2007_01