Ethanesulfonyl chloride → Ethanesulfonic acid [3-(1-ethyl-5-fluoro-indan-1-yl)-1H-indol-7-yl]-amide

반응식

[CH2:1]([C:3]1([C:13]2[C:21]3[C:16](=[C:17]([NH2:22])[CH:18]=[CH:19][CH:20]=3)[NH:15][CH:14]=2)[C:11]2[C:6](=[CH:7][C:8]([F:12])=[CH:9][CH:10]=2)[CH2:5][CH2:4]1)[CH3:2].[CH2:23]([S:25](Cl)(=[O:27])=[O:26])[CH3:24]>>[CH2:1]([C:3]1([C:13]2[C:21]3[C:16](=[C:17]([NH:22][S:25]([CH2:23][CH3:24])(=[O:27])=[O:26])[CH:18]=[CH:19][CH:20]=3)[NH:15][CH:14]=2)[C:11]2[C:6](=[CH:7][C:8]([F:12])=[CH:9][CH:10]=2)[CH2:5][CH2:4]1)[CH3:2]

참가 물질

반응물 2

HCID 11667Ethanesulfonyl chloride

HCID 589417073-(1-Ethyl-5-fluoro-indan-1-yl)-1H-indol-7-ylamine

생성물 1

HCID 58941699Ethanesulfonic acid [3-(1-ethyl-5-fluoro-indan-1-yl)-1H-indol-7-yl]-amide

실험 절차

Utilizing 3-(1-ethyl-5-fluoro-indan-1-yl)-1H-indol-7-ylamine and ethanesulfonyl chloride, the title compound is prepared as in example 15. 0.18 g (35%). LC-MS m/z 387.1 (M++1).

출처 및 근거

ORD 기록: ord-9ddee7899c3e41ddb990dad76578deab
출처 데이터셋: uspto-grants-2010_06
DOI: 10.6084/m9.figshare.5104873.v1
특허 번호: US07728150B2

반응 노트

불러오는 중…