Chlorosuccinimide → 4-Chloro-5-isopropyl-3-trifluoromethylpyrazole

HRID 1372014노트

반응식

HRID 1372014 반응식
[F:1][C:2]([F:12])([F:11])[C:3]1[CH:7]=[C:6]([CH:8]([CH3:10])[CH3:9])[NH:5][N:4]=1.C1C(=O)N([Cl:20])C(=O)C1>CC#N>[Cl:20][C:7]1[C:3]([C:2]([F:1])([F:11])[F:12])=[N:4][NH:5][C:6]=1[CH:8]([CH3:10])[CH3:9]

참가 물질

4

반응물 2

HCID 31398ChlorosuccinimideHCID 230062143-(trifluoroMethyl)-5-isopropyl-1H-pyrazole

생성물 1

HCID 210711494-Chloro-5-isopropyl-3-trifluoromethylpyrazole

시약·촉매·용매 1

HCID 6342Acetonitrile용매

실험 절차

Following protocol L, to the solution of 3-trifluoromethyl-5-isopropyl-pyrazole (0.22 g, 1.23 mmol) in CH3CN (10 mL) was added NCS (0.19 g, 1.43 mmol) in portions with vigorous stirring. The reaction mixture was then heated under reflux for 14 h, cooled and the reaction quenched with saturated NaHCO3, extracted with methylene chloride (2×30 mL) and the combined organic extracts was washed with brine, dried with Na2SO4 and evaporated to give the title compound as a white solid.

후처리

  1. temperatureThe reaction mixture was then heated
  2. temperatureunder reflux for 14 h
  3. temperaturecooled
  4. customthe reaction quenched with saturated NaHCO3
  5. extractionextracted with methylene chloride (2×30 mL)
  6. washthe combined organic extracts was washed with brine
  7. dry with materialdried with Na2SO4
  8. customevaporated

출처 및 근거

ORD 기록
ord-9366c7670978460d8299927a4adb9d2b
출처 데이터셋
uspto-grants-2007_01
특허 번호
US07157464B2

반응 노트

불러오는 중…