Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Dimethylformamide → 2-(3-tert-Butyl-4-chloro-5-trifluoromethyl-pyrazol-1-yl)-1-[4-(4-fluorophenyl)-piperazin-1-yl]-ethanone
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Dimethylformamide | HCID 6228 | — |
| 반응물 | Potassium Carbonate | HCID 11430 | — |
| 반응물 | 1-(Chloroacetyl)-4-(4-fluorophenyl)piperazine | HCID 1848511 | — |
| 반응물 | HCID 178441889 | HCID 178441889 | — |
| 용매 | Ethyl acetate hexane | HCID 21226206 | — |
| 생성물 | 2-(3-tert-Butyl-4-chloro-5-trifluoromethyl-pyrazol-1-yl)-1-[4-(4-fluorophenyl)-piperazin-1-yl]-ethanone | HCID 21071051 | — |
반응 단계
Protocol T was followed using 5-tert-Butyl-4-chloro-3-trifluoromethyl-1H-pyrazole, K2CO3, 2-Chloro-1-[4-(4-fluoro-phenyl)-piperazin-1-yl]-ethanone and DMF. Column chromatography using a solvent mixture (hexane/ethyl acetate=1/1) afforded the title compound as white solid. 1H NMR (400 MHz, CDCl3): 6.94–7.22 (m, 2H), 6.84–6.92 (m, 2H), 5.3 (s, 2H), 3.68–3.8 (m, 2H), 3.6–3.68 (m, 2H), 3.04–3.2 (m, 4H), 1.4 (s, 9H). 13C NMR (400 MHz, CDCl3): 164.8, 119, 118.4, 118.2, 116.2, 116, 54, 51, 50.8, 45.4, 42.2, 30, 29, 27.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US07157464B2 |
| 출처 데이터셋 | uspto-grants-2007_01 |
| ORD ID | ord-b93411dc6e2a43b399b2ee333bdb9e4a |
| 출처 메모 | uspto-grants-2007_01 |