Dimethylformamide → 1-[4-(4-Fluoro-phenyl)-piperazin-1-yl]-2-(4-iodo-3,5-dimethyl-pyrazol-1-yl)-ethanone

HRID 1372097

반응식

HRID 1372097 반응식
[I:1][C:2]1[C:3]([CH3:8])=[N:4][NH:5][C:6]=1[CH3:7].C([O-])([O-])=O.[K+].[K+].Cl[CH2:16][C:17]([N:19]1[CH2:24][CH2:23][N:22]([C:25]2[CH:30]=[CH:29][C:28]([F:31])=[CH:27][CH:26]=2)[CH2:21][CH2:20]1)=[O:18].CN(C=O)C>CCCCCC.C(OCC)(=O)C>[F:31][C:28]1[CH:27]=[CH:26][C:25]([N:22]2[CH2:21][CH2:20][N:19]([C:17](=[O:18])[CH2:16][N:4]3[C:3]([CH3:8])=[C:2]([I:1])[C:6]([CH3:7])=[N:5]3)[CH2:24][CH2:23]2)=[CH:30][CH:29]=1

참가 물질

6

반응물 4

HCID 6228DimethylformamideHCID 11430Potassium CarbonateHCID 971153,5-Dimethyl-4-iodo-1H-pyrazoleHCID 18485111-(Chloroacetyl)-4-(4-fluorophenyl)piperazine

생성물 1

HCID 210710081-[4-(4-Fluoro-phenyl)-piperazin-1-yl]-2-(4-iodo-3,5-dimethyl-pyrazol-1-yl)-ethanone

시약·촉매·용매 1

HCID 21226206Ethyl acetate hexane용매

실험 절차

Protocol T was followed using 4-Iodo-3,5-dimethyl-pyrazole, K2CO3, 2-Chloro-1-[4-(4-fluoro-phenyl)-piperazin-1-yl]-ethanone and DMF. Column chromatography using a solvent mixture (hexane/ethyl acetate=1/1) afforded the title compound as a white solid. 1H NMR (400 MHz, CDCl3); 6.95–7.1 (m, 2H), 6.84–6.92 (dd, 2H), 5.00 (s, 2H), 3.62–3.82 (m, 4H), 3.02–3.12 (m, 4H), 2.22–2.32 (d, 6H). 13C NMR (400 MHz, CDCl3): 165, 158.2, 156.2, 150.2, 146.8, 141.8, 118.8, 115.4, 115.2, 52.8, 51.6, 50.2, 45.2, 42, 14.8, 12.6.

출처 및 근거

ORD 기록
ord-1d3e8dd43a6e4506917c2502201c293f
출처 데이터셋
uspto-grants-2007_01
특허 번호
US07157464B2

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