Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Dimethylformamide → 4-Chloro-5-(5-chloro-thiophen-2-yl)-2-{2-[4-(4-fluoro-phenyl)-piperazin-1-yl]-2-oxo-ethyl}-2H-pyrazole-3-carboxylic acid ethyl ester
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Dimethylformamide | HCID 6228 | — |
| 반응물 | Potassium Carbonate | HCID 11430 | — |
| 반응물 | 1-(Chloroacetyl)-4-(4-fluorophenyl)piperazine | HCID 1848511 | — |
| 반응물 | HCID 178470415 | HCID 178470415 | — |
| 용매 | Ethyl acetate hexane | HCID 21226206 | — |
| 생성물 | 4-Chloro-5-(5-chloro-thiophen-2-yl)-2-{2-[4-(4-fluoro-phenyl)-piperazin-1-yl]-2-oxo-ethyl}-2H-pyrazole-3-carboxylic acid ethyl ester | HCID 58778016 | — |
반응 단계
Protocol T was followed using 4-Chloro-5-(5-chloro-thiophen-2-yl)-2H-pyrazole-3-carboxylic acid ethyl ester, K2CO3, 2-Chloro-1-[4-(4-fluoro-phenyl)-piperazin-1-yl]-ethanone and DMF. Column chromatography using a solvent mixture (hexane/ethyl acetate=2/3) afforded the title compound as a yellow solid. 1H NMR (400 MHz, CDCl3): 7.46–7.48 (m, 1H), 6.94–7.1 (m, 2H), 6.84–6.92 (m, 3H), 5.4 (s, 2H), 4.34–4.4 (q, 2H), 3.62–3.81 (m, 4H), 3.04–3.24 (m, 4H), 1.36–1.44 (m, 3H). MS (ES) M+H) expected=511.41, found 511.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US07157464B2 |
| 출처 데이터셋 | uspto-grants-2007_01 |
| ORD ID | ord-a9d57fdd323540fb85d88551d39676ff |
| 출처 메모 | uspto-grants-2007_01 |