HCID 67406569, 화합물 → HCID 67406325, 화합물

HRID 1372625노트

반응식

HRID 1372625 반응식
C([O:8][CH2:9]/[CH:10]=[CH:11]\[CH2:12][O:13][CH2:14][C@@H:15]1[CH2:19][C@H:18]([F:20])[CH2:17][N:16]1[C:21]([O:23][C:24]([CH3:27])([CH3:26])[CH3:25])=[O:22])C1C=CC=CC=1>C(O)C.[OH-].[Pd+2].[OH-]>[C:24]([O:23][C:21]([N:16]1[CH2:17][C@@H:18]([F:20])[CH2:19][C@H:15]1[CH2:14][O:13][CH2:12][CH2:11][CH2:10][CH2:9][OH:8])=[O:22])([CH3:27])([CH3:26])[CH3:25]

참가 물질

4

반응물 1

HCID 67406569HCID 67406569, 화합물

생성물 1

HCID 67406325HCID 67406325, 화합물수율 68.6%

시약·촉매·용매 2

HCID 9942167Palladium hydroxide촉매HCID 702Ethanol용매

실험 절차

In ethanol (200 ml) were suspended (Z)-(2S,4S)-2-(4-benzyloxy-2-butenyloxymethyl)-1-(tert-butoxycarbonyl)-4-fluoropyrrolidine (4.58 g, 12.1 mmol) and 20% palladium hydroxide (4.0 g). The resulting suspension was subjected to catalytic hydrogenation at room temperature under normal pressure for 14 hours. The catalyst was then filtered off and the filtrate was distilled under reduced pressure to remove the solvent. The residue was purified by chromatography on a silica gel column (silica gel: 100 g), whereby from chloroform/acetone (10/1) eluate fractions, the title compound (2.42 g, 67%) was obtained as a colorless oil.

후처리

  1. filtrationThe catalyst was then filtered off
  2. distillationthe filtrate was distilled under reduced pressure
  3. customto remove the solvent
  4. customThe residue was purified by chromatography on a silica gel column (silica gel: 100 g), whereby from chloroform/acetone (10/1) eluate fractions

출처 및 근거

ORD 기록
ord-1241dc4f90d44816bd17b9d4d852b94a
출처 데이터셋
uspto-grants-2007_01
특허 번호
US07157487B2

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