HCID 21072520, 화합물 → HCID 86596829, 화합물

HRID 1372958노트

반응식

HRID 1372958 반응식
[NH2:1][C@@H:2]1[C:8](=[O:9])[N:7]([CH3:10])[C:6]2[CH:11]=[CH:12][CH:13]=[CH:14][C:5]=2[C:4]2[CH:15]=[CH:16][CH:17]=[CH:18][C:3]1=2.[F:19][C:20]([F:33])([C:29]([F:32])([F:31])[F:30])[CH2:21][NH:22][C:23](=[O:28])[CH2:24][C:25](O)=[O:26]>>[CH3:10][N:7]1[C:8](=[O:9])[C@@H:2]([NH:1][C:25](=[O:26])[CH2:24][C:23]([NH:22][CH2:21][C:20]([F:33])([F:19])[C:29]([F:30])([F:32])[F:31])=[O:28])[C:3]2[CH:18]=[CH:17][CH:16]=[CH:15][C:4]=2[C:5]2[CH:14]=[CH:13][CH:12]=[CH:11][C:6]1=2

참가 물질

3

반응물 2

HCID 21072520HCID 21072520, 화합물HCID 59100698(7S)-7-Amino-5,7-dihydro-5-methyl-6H-dibenz[b,d]azepin-6-one

생성물 1

HCID 86596829HCID 86596829, 화합물

실험 절차

(S)-7-Amino-5-methyl-5H,7H-dibenzo[b,d]azepin-6-one was coupled with N-(2,2,3,3,3-pentafluoro-propyl)-malonamic acid in analogy to the description in example 73 to yield N-((S)-5-Methyl-6-oxo-6,7-dihydro-5H-dibenzo[b,d]azepin-7-yl)-N′-(2,2,3,3,3-pentafluoro-propyl)-malonamide as white solid.

출처 및 근거

ORD 기록
ord-dd27025e7d7647e58696e37e15552538
출처 데이터셋
uspto-grants-2007_01
특허 번호
US07160875B2

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