Potassium Carbonate → 4-(4-Bromo-2-fluorophenylamino)-7-(2,3-epoxypropoxy)-6-methoxyquinazoline

HRID 1372993노트

반응식

HRID 1372993 반응식
Cl[C:2]1[CH:7]=[CH:6][C:5]([NH:8][C:9]2[C:18]3[C:13](=[CH:14][C:15]([O:21][CH2:22][CH:23]4[O:25][CH2:24]4)=[C:16]([O:19][CH3:20])[CH:17]=3)[N:12]=[CH:11][N:10]=2)=[C:4]([F:26])[CH:3]=1.OC1C=C2C(C(NC3C=CC([Br:45])=CC=3F)=NC=N2)=CC=1OC.BrCC1OC1.C(=O)([O-])[O-].[K+].[K+]>CN(C=O)C>[Br:45][C:2]1[CH:7]=[CH:6][C:5]([NH:8][C:9]2[C:18]3[C:13](=[CH:14][C:15]([O:21][CH2:22][CH:23]4[O:25][CH2:24]4)=[C:16]([O:19][CH3:20])[CH:17]=3)[N:12]=[CH:11][N:10]=2)=[C:4]([F:26])[CH:3]=1

참가 물질

6

반응물 4

HCID 11430Potassium CarbonateHCID 18430EpibromohydrinHCID 114402734-(4-Chloro-2-fluorophenylamino)-7-(2,3-epoxypropoxy)-6-methoxyquinazolineHCID 1355038524-[(4-Bromo-2-fluorophenyl)amino]-6-methoxy-7-quinazolinol

생성물 1

HCID 179746094-(4-Bromo-2-fluorophenylamino)-7-(2,3-epoxypropoxy)-6-methoxyquinazoline수율 26%

시약·촉매·용매 1

HCID 6228Dimethylformamide용매

실험 절차

Using a similar procedure to the one described in Example 2 for the preparation of 4-(4-chloro-2fluorophenylamino)-7-(2,3-epoxypropoxy)-6-methoxyquinazoline, 7-hydroxy-6-methoxy-4-(2-fluoro-4-bromophenylamino)quinazoline (6 g, 16.5 mmol) was reacted with 1-bromo-2,3-epoxypropane (1.7 ml, 19.8 mmol) in DMF (50 ml) in the presence of potassium carbonate (4.55 g, 3.3 mmol) and purified as described to give 4-(4-bromo-2-fluorophenylamino)-7-(2,3-epoxypropoxy)-6-methoxyquinazoline (1.8 g, 26%).

후처리

  1. custompurified

출처 및 근거

ORD 기록
ord-6816d8f0ad844431b25d825db81a66d3
출처 데이터셋
uspto-grants-2007_01
특허 번호
US07160889B2

반응 노트

불러오는 중…