1,1'-Biphenyl, 4-(bromomethyl)- → 3-benzyl-6-(biphenyl-4-ylmethylsulfanyl)-5-methyl-1H-pyrimidine-2,4-dione
반응식
[CH2:1]([N:8]1[C:13](=[O:14])[C:12]([CH3:15])=[C:11]([SH:16])[NH:10][C:9]1=[O:17])[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.[C:18]1([C:24]2[CH:31]=[CH:30][C:27]([CH2:28]Br)=[CH:26][CH:25]=2)[CH:23]=[CH:22][CH:21]=[CH:20][CH:19]=1>>[CH2:1]([N:8]1[C:13](=[O:14])[C:12]([CH3:15])=[C:11]([S:16][CH2:28][C:27]2[CH:30]=[CH:31][C:24]([C:18]3[CH:19]=[CH:20][CH:21]=[CH:22][CH:23]=3)=[CH:25][CH:26]=2)[NH:10][C:9]1=[O:17])[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1참가 물질
3
실험 절차
The product of Example 2, Step (C) was treated with 4-phenylbenzyl bromide as in Example 2, Step (D) to give 3-benzyl-6-(biphenyl-4-ylmethylsulfanyl)-5-methyl-1H-pyrimidine-2,4-dione. MS (APCI), m/z ([M+H]+) 415.
출처 및 근거
- ORD 기록
- ord-8a022b6bd5b34593bb682e97f09e4443
- 출처 데이터셋
- uspto-grants-2007_01
- 특허 번호
- US07160893B2
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