Sodium Iodide → 4-Iodomethyl-5-methyl-2-naphthalen-2-yloxazole

HRID 1373159노트

반응식

HRID 1373159 반응식
Cl[CH2:2][C:3]1[N:4]=[C:5]([C:9]2[CH:18]=[CH:17][C:16]3[C:11](=[CH:12][CH:13]=[CH:14][CH:15]=3)[CH:10]=2)[O:6][C:7]=1[CH3:8].[I-:19].[Na+].C(OC)(C)(C)C>CC(C)=O>[I:19][CH2:2][C:3]1[N:4]=[C:5]([C:9]2[CH:18]=[CH:17][C:16]3[C:11](=[CH:12][CH:13]=[CH:14][CH:15]=3)[CH:10]=2)[O:6][C:7]=1[CH3:8]

참가 물질

5

반응물 3

HCID 5238Sodium IodideHCID 15413tert-Butyl methyl etherHCID 121580734-(Chloromethyl)-5-methyl-2-(naphthalen-2-yl)-1,3-oxazole

생성물 1

HCID 210742684-Iodomethyl-5-methyl-2-naphthalen-2-yloxazole

시약·촉매·용매 1

HCID 180Acetone용매

실험 절차

1.8 g of 4-chloromethyl-5-methyl-2-naphthalen-2-yloxazole and 3 g of sodium iodide in 150 ml of acetone are heated under reflux for 2 hours. After the reaction mixture has been cooled, 300 ml of methyl tert-butyl ether are added, the mixture is washed three times with saturated Na2S2O3 solution and dried over MgSO4 and the solvents are then removed under reduced pressure. This gives 2.7 g of 4-iodomethyl-5-methyl-2-naphthalen-2-yloxazole as a light-yellow solid.

후처리

  1. temperatureunder reflux for 2 hours
  2. temperatureAfter the reaction mixture has been cooled
  3. washthe mixture is washed three times with saturated Na2S2O3 solution
  4. dry with materialdried over MgSO4
  5. customthe solvents are then removed under reduced pressure

출처 및 근거

ORD 기록
ord-fd05c981796b448b8502a53815ae871b
출처 데이터셋
uspto-grants-2007_01
특허 번호
US07160911B2

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