Sodium hydroxide tetrahydrofuran → 2-[3-Isopropyloxy-5-(2-fluorophenysulfonylmethyl)benzoylamino]-5-pridine carboxlic acid

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Standard ester hydrolysis (2M NaOH/THF), as described in Example A, of methyl 2-[3-isopropyloxy-5-(2-fluorophenylsulfonyl) methyl benzoyl]aminopyridine-5-carboxylate gave the title compound as a pale yellow solid, 1H NMR δ (300 MHz, d6-DMSO): 1.12 (d, 6H); 4.58–4.66 (m, 1H); 4.79 (s, 2H); 6.98 (s, 1H); 7.30–7.41 (m, 2H); 7.43 (s, 1H); 7.48–7.63 (m, 2H); 7.72–7.81 (m, 1H); 8.30 (s, 2H); 8.86 (S, 1H); 11.08 (br s, 1H); m/z 473 (M+H)+, 471

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