7-{5-[4-(6-Cyclopropyl-pyridin-2-yl)-piperazin-1-yl]-pent-1-enyl}-3,4-dihydro-1H-[1,8]naphthyridin-2-one → 7-{5-[4-(6-Cyclopropyl-pyridin-2-yl)-piperazin-1-yl]-pentyl}-3,4-dihydro-1H-[1,8]naphthyridin-2-one
반응식
[CH:1]1([C:4]2[N:9]=[C:8]([N:10]3[CH2:15][CH2:14][N:13]([CH2:16][CH2:17][CH2:18][CH:19]=[CH:20][C:21]4[N:30]=[C:29]5[C:24]([CH2:25][CH2:26][C:27](=[O:31])[NH:28]5)=[CH:23][CH:22]=4)[CH2:12][CH2:11]3)[CH:7]=[CH:6][CH:5]=2)[CH2:3][CH2:2]1>C1COCC1.[Pd]>[CH:1]1([C:4]2[N:9]=[C:8]([N:10]3[CH2:15][CH2:14][N:13]([CH2:16][CH2:17][CH2:18][CH2:19][CH2:20][C:21]4[N:30]=[C:29]5[C:24]([CH2:25][CH2:26][C:27](=[O:31])[NH:28]5)=[CH:23][CH:22]=4)[CH2:12][CH2:11]3)[CH:7]=[CH:6][CH:5]=2)[CH2:2][CH2:3]1참가 물질
4
반응물 1
생성물 1
시약·촉매·용매 2
실험 절차
7-{5-[4-(6-Cyclopropyl-pyridin-2-yl)-piperazin-1-yl]-pent-1-enyl}-3,4-dihydro-1H-[1,8]naphthyridin-2-one (0.347 g, 0.831 mmol) was hydrogenated using 20% Pd/C in THF for 15 h. The reaction was filtered and concentrated. Recrystallization from hot CH3CN gave the title compound as a white powder (288 mg, 0.686 mmol, 83%). MS: APCI: M+1: 420.3 (Exact Mass: 419.27).