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Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
HRID 1373615생성일: 2026년 10월 27일

1-(1-Naphthyl)piperazine hydrochloride → 7-[4-(4-Naphthalen-1-yl-piperazin-1-yl)-butoxy]-5-trifluoromethyl-3,4-dihydro-1H-[1,8]naphthyridin-2-one

https://huagongshe.com/reaction/1373615

반응식

참여 물질

역할이름HCID투입량
반응물1-(1-Naphthyl)piperazine hydrochlorideHCID 2737391—
반응물4-(7-Oxo4-trifluoromethyl-5,6,7,8-tetrahydro-[1,8]naphthyridin-2-yloxy)-butyraldehydeHCID 21073376—
생성물7-[4-(4-Naphthalen-1-yl-piperazin-1-yl)-butoxy]-5-trifluoromethyl-3,4-dihydro-1H-[1,8]naphthyridin-2-oneHCID 21073813—

반응 단계

In a manner similar to that of other examples above, 1-naphthalen-1-yl-piperazine hydrochloride was coupled by reductive amination to 4-(7-oxo-4-trifluoromethyl-5,6,7,8-tetrahydro-[1,8]naphthyridin-2-yloxy)-butyraldehyde followed by typical workup and purification to give the title compound. MS: APCI: M+1: 499.1 (Exact Mass: 489.22).

출처 및 근거

DOI10.6084/m9.figshare.5104873.v1
특허 번호US07160888B2
출처 데이터셋uspto-grants-2007_01
ORD IDord-b8c9c417c92f47c78a1a2096b13e86d6
출처 메모uspto-grants-2007_01