Benzyl Alcohol → Benzoic Acid

HRID 13737

반응식

HRID 13737 반응식
Br([O-])(=O)=O.[Na+].[CH2:6]([OH:13])[C:7]1[CH:12]=[CH:11][CH:10]=[CH:9][CH:8]=1.CC[O:16]CC>C(#N)C.O>[C:6]([OH:16])(=[O:13])[C:7]1[CH:12]=[CH:11][CH:10]=[CH:9][CH:8]=1

참가 물질

5

반응물 3

HCID 244Benzyl AlcoholHCID 3283Diethyl EtherHCID 23668195Sodium Bromate

생성물 1

HCID 243Benzoic Acid수율 90%

시약·촉매·용매 1

HCID 18373917Acetonitrile--water (1/1)용매

반응 조건

온도
80 °C

실험 절차

A mixture of Ceiv catalyst from Example 47 (0.08 g), sodium bromate (0.3 g) and benzyl alcohol (0.216 g, 2 mmol) in acetonitrile:water (5:7, 12 ml) was stirred at 80° C. for 40 h under an atmosphere of nitrogen. On cooling ether (70 ml) was added and the catalyst was filtered off. The organic layer was separated and the aqueous phase was extracted with ether (2×50 ml). The combined organic extracts were washed with water (25 ml), dried with anhydrous magnesium sulphate and concentrated to give benzoic acid as a white solid (0.22 g, 90%). M.p. 120° C., lit. 120-122° C.

후처리

  1. additionwas added
  2. filtrationthe catalyst was filtered off
  3. customThe organic layer was separated
  4. extractionthe aqueous phase was extracted with ether (2×50 ml)
  5. washThe combined organic extracts were washed with water (25 ml)
  6. dry with materialdried with anhydrous magnesium sulphate
  7. concentrationconcentrated

출처 및 근거

ORD 기록
ord-bd280309d1274ad4b0b18844835c296f
출처 데이터셋
uspto-grants-2010_06
특허 번호
US07728159B2

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