6-Nitro-2,3-dihydro-benzo[1,4]oxathiine-4,4-dioxide → 6-Amino-2,3-dihydro-1,4

HRID 1373719노트

반응식

HRID 1373719 반응식
[N+:1]([C:4]1[CH:5]=[CH:6][C:7]2[O:12][CH2:11][CH2:10][S:9](=[O:14])(=[O:13])[C:8]=2[CH:15]=1)([O-])=O.[H][H]>C1COCC1.CO.[Pd]>[NH2:1][C:4]1[CH:5]=[CH:6][C:7]2[O:12][CH2:11][CH2:10][S:9](=[O:14])(=[O:13])[C:8]=2[CH:15]=1

참가 물질

6

반응물 2

HCID 219881646-Nitro-2,3-dihydro-benzo[1,4]oxathiine-4,4-dioxideHCID 178418361HCID 178418361, 화합물

생성물 1

HCID 219881516-Amino-2,3-dihydro-1,4수율 46.4%

시약·촉매·용매 3

HCID 23938Palladium촉매HCID 887Methanol용매HCID 8028Tetrahydrofuran용매

실험 절차

0.917 g 6-Nitro-2,3-dihydro-benzo[1,4]oxathiine-4,4-dioxide (from g)) were hydrogenated in a mixture of 20 ml THF and 20 ml MeOH with 0.90 g 5% Pd—C at atmospheric hydrogen pressure for 90 min. at room temperature. The catalyst was filtered off, the filtrate evaporated and the residue chromatographed on silica to yield 370 mg of the title compound.

후처리

  1. filtrationThe catalyst was filtered off
  2. customthe filtrate evaporated
  3. customthe residue chromatographed on silica

출처 및 근거

ORD 기록
ord-ef96b7afa3474a44a6945b1e95e04c89
출처 데이터셋
uspto-grants-2007_01
특허 번호
US07163941B2

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