Water → 4-(4-Cyanophenyl)butyl methanesulfonate

HRID 1374088노트

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HRID 1374088 반응식
[CH3:1][S:2](Cl)(=[O:4])=[O:3].[OH:6][CH2:7][CH2:8][CH2:9][CH2:10][C:11]1[CH:18]=[CH:17][C:14]([C:15]#[N:16])=[CH:13][CH:12]=1.C(N(CC)CC)C.O>ClCCl>[CH3:1][S:2]([O:6][CH2:7][CH2:8][CH2:9][CH2:10][C:11]1[CH:12]=[CH:13][C:14]([C:15]#[N:16])=[CH:17][CH:18]=1)(=[O:4])=[O:3]

참가 물질

6

반응물 4

HCID 962WaterHCID 8471TriethylamineHCID 31297Methanesulfonyl chlorideHCID 185403804-(4-Hydroxybutyl)benzonitrile

생성물 1

HCID 185404244-(4-Cyanophenyl)butyl methanesulfonate

시약·촉매·용매 1

HCID 6344Dichloromethane용매

실험 절차

Methanesulfonyl chloride (2.32 mL, 30 mmol) was added to a cooled is (0° C.), stirred solution of 4-(4-hydroxybutyl)benzonitrile (from step (ii) above, 5.2 g, 29.7 mmol) and triethylamine (4.35 mL) in dichloromethane (50 mL). The resulting mixture was stirred for 4 h before water (150 mL) was added, and the organic layer separated, dried and concentrated to give the sub-title compound. This product was used directly in the next step without further purification.

후처리

  1. custom(0° C.)
  2. additionwas added
  3. customthe organic layer separated
  4. customdried
  5. concentrationconcentrated

출처 및 근거

ORD 기록
ord-edfef166958143b0bcc91c2e89d8d9cb
출처 데이터셋
uspto-grants-2007_01
특허 번호
US07164017B2

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